IGF-1LR3

Product Overview

IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor-1) is a synthetic, bioengineered analog of native human IGF-1, modified to enhance biological stability and receptor binding affinity in controlled research environments.

Structurally, IGF-1 LR3 differs from endogenous IGF-1 by a substitution of arginine for glutamic acid at position 3 and the addition of a 13-amino-acid extension on the N-terminus. These modifications result in an increased half-life and significantly reduced binding to IGF-binding proteins (IGFBPs), allowing for prolonged activity and greater availability for receptor interaction.

In scientific research, IGF-1 LR3 is investigated for its ability to activate the IGF-1 receptor (IGF-1R) and downstream PI3K/Akt and MAPK signaling pathways, which are central to protein synthesis, glucose metabolism, and cell survival. Its anabolic-like actions have been explored in models evaluating skeletal muscle hypertrophy, tissue regeneration, neural development, and metabolic function. Studies also indicate potential roles in insulin sensitivity, myocyte differentiation, and connective-tissue remodeling, positioning IGF-1 LR3 as a leading compound for research on cellular longevity and anabolic regulation.

IGF-1 LR3’s extended duration of action—lasting up to 20–30 hours in some research models—makes it especially useful for evaluating growth-factor kinetics, receptor desensitization, and metabolic feedback loops. Its broad relevance extends across endocrine physiology, muscle repair, and regenerative biology, providing scientists with a highly stable platform for examining growth-factor signaling dynamics.

Key Research Benefits

• Studied for its activation of IGF-1 receptor pathways and PI3K/Akt signaling

• Supports research on cell growth, differentiation, and metabolic regulation

• May aid in understanding muscle repair, tissue regeneration, and connective-tissue adaptation

• Explored for its role in insulin sensitivity, protein synthesis, and cellular energy balance

• Demonstrates extended half-life and stability, allowing for prolonged receptor engagement in research models

Disclaimer: All products, including IGF-1 LR3, are sold for laboratory and research purposes only.
Not for human consumption, medical, or veterinary use.